Vibration-controlled transient elastography (VCTE) for liver stiffness measurement (LSM) demonstrates comparable prognostic accuracy to liver biopsy for predicting liver-related events (LREs) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). A study involving 3,532 adults indicated that LSM is strongly associated with liver events, with a mean baseline LSM of 8.8 kPa among studied patients. After a median follow-up of 56.6 months, both methods yielded similar performance metrics, suggesting LSM may serve as a practical surrogate for histology in clinical settings.
1. VCTE provides equivalent prognostic accuracy to liver biopsy. 2. Study involved 3,532 patients with MASLD. 3. 3.6% of patients developed liver-related events after 56.6 months. 4. Median baseline liver stiffness measurement was 8.8 kPa. 5. Both methods showed nearly identical performance metrics. 6. LSM may serve as a practical alternative for histology in clinical trials.
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