Turning Proteins into DNA for Ultra-Sensitive Sequencing - Summary - MDSpire
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Turning Proteins into DNA for Ultra-Sensitive Sequencing

Stanford researchers repurpose DNA sequencing technology to read proteins at single-molecule resolution, complementing – and potentially surpassing – mass spectrometry

  • April 2, 2026

  • 2 min

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Stanford University bioengineers have developed a groundbreaking method called 'reverse translation' that enables the reading of proteins by converting them into DNA. This innovative approach tags amino acids with DNA barcodes as they are cleaved from peptides, creating a sequence that can be amplified and read using low-cost DNA sequencing technology. The technique boasts an accuracy of around 98% and significantly increases detection sensitivity, allowing for the identification of rare peptides in low-abundance samples. This advancement could enhance our understanding of cellular heterogeneity and improve therapy outcomes.

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Turning Proteins into DNA for Ultra-Sensitive Sequencing

  • April 2, 2026

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