Evaluating IPFP Steroid Injections in OA
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By
January 27, 2026
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3 min
A multicenter, double-blind, placebo-controlled trial found that glucocorticoid injections into the infrapatellar fat pad do not significantly reduce knee pain or effusion synovitis volume in patients with inflammatory knee osteoarthritis after 12 weeks. The study involved 60 adults aged 45 and older, all with MRI-confirmed Hoffa synovitis and effusion synovitis. Although the primary endpoints were unmet, some secondary outcomes showed improvements for the treatment group. Limitations include a small sample size and a short follow-up period. The research was led by Dr. Yan Zhang from Zhujiang Hospital, Southern Medical University, China.
1. Glucocorticoid injections into the infrapatellar fat pad do not significantly alleviate knee pain or effusion. 2. Study involved 60 adult participants aged 45 and older. 3. Follow-up duration was 12 weeks, with MRI-confirmed Hoffa and effusion synovitis. 4. Primary endpoints were not met but some secondary outcomes favored the glucocorticoid group. 5. Study limitations include modest sample size and short follow-up period. 6. Research was led by Dr. Yan Zhang of Zhujiang Hospital, Southern Medical University.
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