Fingerprinting Diet-Driven Changes in the Gut Volatilome
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February 4, 2026
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2 min
A study reveals that dietary intervention and probiotic supplementation lead to significant changes in the human fecal volatilome. Researchers analyzed fecal samples from individuals with non-celiac gluten/wheat sensitivity undergoing a dietary protocol, revealing coordinated shifts in volatile organic compound profiles related to gut microbial activity. By employing comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry, the study identified approximately 270 annotated VOCs, enhancing understanding of the metabolic response to dietary changes and providing a platform for further biomarker discovery in personalized nutrition.
1. Study examines changes in human fecal volatilome. 2. Dietary intervention included gluten-free diet and probiotics. 3. Utilized GC×GC-TOFMS for analysis. 4. Identified approximately 270 VOCs. 5. Coordinated shifts in VOCs linked to gut microbiota were observed. 6. Method allows for broad detection of metabolic variations. 7. Study expands catalog of human fecal volatiles by 20%. 8. Offers insights into personalized nutrition and biomarker discovery.
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