Research from King's College London indicates that successful endodontic therapy for apical periodontitis (AP) may enhance glucose and lipid metabolism while reducing systemic inflammation. In a two-year study analyzing 44 serum metabolites in 65 adults, significant changes were observed in amino acids, glucose, and lipid levels. Notably, branched-chain amino acids decreased post-treatment, suggesting improved glucose tolerance. The study proposes that endodontic treatment might restore TCA cycle function, promoting periapical healing and potentially lowering cardiovascular disease risk.
1. Successful endodontic treatment may improve glucose/lipid metabolism.2. Study analyzed 44 serum metabolites in 65 adults with AP.3. Significant decrease in branched-chain amino acids post-treatment.4. TCA cycle function may be restored, aiding periapical healing.5. Serum tryptophan could serve as a prognostic biomarker.6. Study had limitations, including small sample size.7. No causation was established; further studies needed.8. Results parallel findings in periodontal therapy research.
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