From the Journals

Proteomic Profiling Defines Vascular Cell States

Label-free LC–MS profiles nearly 5,000 cells, resolving smooth muscle subtypes and disease-associated phenotypes 

  • March 18, 2026

  • 2 min

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Researchers at Cedars-Sinai Medical Center introduced a label-free single-cell proteomics workflow to explore complex vascular tissue, specifically studying Marfan syndrome. This method utilized liquid chromatography-mass spectrometry to analyze around 5,000 individual cells and quantify approximately 500 proteins per cell. The study identified major aortic cell types and distinct smooth muscle cell phenotypes associated with the disease. Notable protein changes, such as increased LRP1 and PRSS2 levels, were linked to altered phenotypes, which may influence aneurysm progression.

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Proteomic Profiling Defines Vascular Cell States

  • March 18, 2026

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