From the Journals

Can Gene Scores Help Detect Sepsis?

Multicenter study assesses diagnostic accuracy of rapid transcriptomic testing

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A multicenter study published in the European Journal of Clinical Microbiology & Infectious Diseases demonstrated that a rapid gene expression blood test can effectively differentiate sepsis from noninfectious critical illness in adults in the ICU. The test, analyzing expressions of PLA2G7 and PLAC8, yielded an accuracy with an area under the curve of 0.84. While the test performed better than C-reactive protein and comparably to procalcitonin, it revealed highest accuracy in Band 4, with a positive predictive value of 92%, emphasizing the challenges in early sepsis identification.

Original Source(s)

Can Gene Scores Help Detect Sepsis?

  • by Jess Allerton

  • March 12, 2026

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