A Simpler, Smarter CHO Strategy for High-Quality Bispecifics
Here’s how next-generation cell line and manufacturing methods can boost productivity, improve purity, and remove bottlenecks in bispecific antibody development
In a recent webinar, practical strategies to enhance bispecific antibody production using CHO cell lines were discussed, with a focus on an antibiotic-free platform leveraging the glutamine synthetase selection marker. This innovative approach aims to simplify the development process of these complex therapeutics, ensuring high yields and purity while utilizing advanced molecular design and continuous manufacturing techniques. Just-Evotec Biologics aims to revolutionize biotherapeutics access through optimized bioprocessing workflows.
1. Bispecific antibodies can bind multiple antigens. 2. CHO cell lines facilitate complex antibody production. 3. Glutamine synthetase is essential for selection. 4. The J.MD platform integrates AI for molecule design. 5. Split GS method enhances antibody expression without antibiotics. 6. Continuous manufacturing improves efficiency. 7. Empirical optimization of plasmid ratios boosts yields.