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ALS Drug Misses Trial Goals

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Corcept Therapeutics' experimental drug, dazucorilant, did not meet the main goal of slowing the decline in motor skills and functional criteria for patients with amyotrophic lateral sclerosis (ALS) in a mid-stage trial. Although patients receiving dazucorilant experienced more gastrointestinal upset and no deaths were observed in the 300 mg dose group, five deaths were reported in the placebo group. The study results will be presented next year, and an open-label, long-term extension study will continue, assessing overall survival in March 2025.

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