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Comparing Brain Stimulation Strategies for Depression

Two transcranial magnetic stimulation protocols produced different short-term outcomes in patients with major depressive disorder

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A randomized clinical trial evaluated two transcranial magnetic stimulation (TMS) strategies for major depressive disorder: intermittent theta-burst stimulation (iTBS) and a sequential bilateral protocol. The results indicated that patients receiving iTBS showed significantly greater improvements in depressive symptoms and emotion regulation over a two-week treatment period compared to the sequential protocol. While both approaches modulate prefrontal brain circuits, iTBS was more effective in enhancing cognitive reappraisal and reducing anxiety symptoms. However, the study's limitations, including the lack of a sham control, highlight the need for further research.

Original Source(s)

Comparing Brain Stimulation Strategies for Depression

Two transcranial magnetic stimulation protocols produced different short-term outcomes in patients with major depressive disorder

  • by Henry Thomas

  • March 5, 2026

  • 3 min

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