At-Home Brain Stimulation for Alzheimer’s
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By
February 13, 2026
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3 min
A recent randomized clinical trial published in JAMA Network Open investigated the safety, feasibility, and biological effects of home-based gamma transcranial alternating current stimulation (tACS) in patients with prodromal or mild Alzheimer's disease (AD). Conducted with 50 biomarker-confirmed patients aged 67 on average, the trial showed that daily stimulation improved cognitive measures without significant adverse effects or serious events reported. Although some neurophysiologic improvements were noted, plasma biomarkers remained unchanged, indicating the need for larger studies to further evaluate this intervention's potential.
1. Home-based gamma tACS evaluated for Alzheimer's treatment. 2. Study included 50 patients with mild AD. 3. Daily stimulation improved cognitive measures significantly. 4. No serious adverse effects reported during treatment. 5. Plasma biomarkers did not show significant changes. 6. Neurophysiologic measures indicated biologic engagement. 7. Further research needed for evaluating long-term effects. 8. Study funded by the Italian Ministry of Health and European programs.
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