Oligonucleotides have surged in importance since the COVID-19 pandemic, with applications spanning personalized medicine and mRNA technology. Their analysis presents challenges, given the need for precise differentiation of nearly identical sequences. Traditional reversed-phase columns are ineffective due to the polar nature of oligonucleotides; however, ion-pair reversed-phase (IP-RP) chromatography has emerged as the preferred analytical method. The new Sepapure oliGO column offers high precision, robustness, and affordability, facilitating advances in oligonucleotide research.
1. Oligonucleotides are crucial in therapeutic research post-pandemic. 2. Precise analysis is essential but challenging. 3. Traditional columns fail for oligonucleotide analysis. 4. IP-RP chromatography is the preferred method. 5. The Sepapure oliGO column offers high precision and durability. 6. Affordability is a focus to boost research. 7. Successful method transfer from existing products with low back pressure improvements.
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