From the Journals

Tumor Budding May Predict Survival in Head and Neck Cancer

Tumor budding emerges as a practical histologic marker, as clinicians seek low-cost predictors of occult metastasis in surgically treated patients.

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A study involving 98 patients with head and neck squamous cell carcinoma revealed that high tumor budding is significantly associated with worse prognosis and increased lymph node metastasis. Patients with more than four tumor buds had a 5-year overall survival rate of just 26%, compared to 85% for those with low tumor budding. This biomarker was identified as an independent predictor of survival, enhancing awareness of disease aggressiveness. The study emphasizes the potential for tumor budding to aid in treatment decisions, particularly regarding neck dissection.

Original Source(s)

Tumor Budding May Predict Survival in Head and Neck Cancer

Tumor budding emerges as a practical histologic marker, as clinicians seek low-cost predictors of occult metastasis in surgically treated patients.

  • by Stanley Gajete

  • August 14, 2025

  • 3 min

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