Distinct gut microbial signatures linked to coronary artery disease (CAD) were identified through shotgun metagenomic sequencing in a study published in mSystems. Researchers analyzed fecal samples from 14 CAD patients and 28 healthy controls, revealing significant differences in bacterial taxa and metabolic pathways. Pro-inflammatory bacterial taxa were noted to be enriched in CAD patients, while key short-chain fatty acid-producing bacteria were depleted. Findings highlighted the predictive potential of gut microbiota features for CAD through random forest classifiers, indicating a complex interaction between gut microbiome alterations and cardiovascular disease.
1. Shotgun metagenomic sequencing revealed gut microbial signatures associated with CAD. 2. 15 bacterial species showed differential abundance in CAD patients vs. controls. 3. Pro-inflammatory taxa enriched, while SCFA-producing bacteria depleted in CAD. 4. Key metabolic pathways identified: urea cycle, glycolysis. 5. Predictive modeling achieved high mean AUC using gut microbiota features. 6. Small sample size may affect generalizability. 7. Study design limits causal inference regarding gut microbiome and CAD.
Listen Tab content
