From the Journals

CKD Markers Linked to Cognitive Risk

In adults with chronic kidney disease, higher proteinuria and lower estimated glomerular filtration rate are associated with increased risk of incident cognitive impairment.

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A recent study highlights the significant link between chronic kidney disease (CKD) severity and cognitive impairment. Analyzing data from 5,607 adults, researchers found that patients with both a reduced estimated glomerular filtration rate (eGFR) and a urinary protein to creatinine ratio (UPCR) of 150 mg/g or more showed a 38% increased risk of global cognitive impairment. Notably, each standard deviation increase in UPCR corresponded to a 21% greater likelihood of impaired attention and processing speed. Conducted through the CRIC Study, the findings underscore CKD's impact on cognitive health.

Original Source(s)

CKD Markers Linked to Cognitive Risk

In adults with chronic kidney disease, higher proteinuria and lower estimated glomerular filtration rate are associated with increased risk of incident cognitive impairment.

  • by Kathryn Wighton

  • February 17, 2026

  • 3 min

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