GLP-1 drugs pose no cancer risk, review finds
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December 11, 2025
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4 min
A systematic review and meta-analysis highlighted that glucagon-like peptide-1 receptor agonists (GLP-1RAs) do not significantly increase overall cancer risk after 70 weeks of follow-up, as stated by Cho-Han Chiang, MD, from Harvard Medical School. While early studies raised concerns about links to certain cancers, recent data suggests consistency in reassuring results regarding cancer risk. Ongoing monitoring and longer-term trials are essential to clarify the long-term safety of GLP-1RAs, especially for those with a history of cancer.
1. GLP-1RAs do not significantly increase overall cancer risk. 2. Study involved 48 randomized trials with 94,245 participants. 3. Moderate-certainty evidence for little or no effect on thyroid and pancreatic cancers. 4. Observational studies show conflicting results regarding obesity-related cancers. 5. Longer follow-up studies needed to assess long-term cancer risk.
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