Cutaneous SCC Trends Across Sex and Age
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By
February 2, 2026
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3 min
A recent study analyzing Danish national registry data reveals an alarming increase in the incidence rates of carcinoma in situ, which surged at approximately twice the rate of invasive cutaneous squamous cell carcinoma (cSCC) between 2005 and 2023. The research, based on 109,787 confirmed cSCC, carcinoma in situ, and keratoacanthoma cases, indicates that by 2023, cSCC prevalence reached 131.6 per 100,000 in males and 77.7 in females, while carcinoma in situ incidence exhibited significant growth especially post-2018. The research underscores the need for improved diagnostic practices and surveillance to address rising skin cancer rates.
1. Carcinoma in situ incidence increased significantly over invasive cSCC. 2. By 2023, cSCC rates were 131.6 (males) and 77.7 (females) per 100,000. 3. Carcinoma in situ saw a 6.4% annual increase in males post-2018. 4. The study analyzed 109,787 confirmed skin cancer cases. 5. KA incidence decreased; significant for public health implications on skin cancer. 6. Females aged 40-59 had increasing rates of keratinocyte neoplasms. 7. Limitations included diagnostic practice variations.
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