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CRS Trial Reveals Surgery Divide

MACRO qualitative study explores why patients differ in attitudes toward endoscopic sinus surgery.

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A qualitative study within the MACRO trial assessed patient and clinician experiences regarding treatments for chronic rhinosinusitis (CRS). Conducted across 21 ENT centers in the UK, the study involved 514 patients assigned to endoscopic sinus surgery (ESS), clarithromycin, or placebo. Interviews with 20 patients and 17 clinicians revealed diverse motivations for trial participation and mixed experiences. ESS showed significant improvement in symptoms, while clarithromycin had limited efficacy. Successful implementation of findings may require improved communication and resource allocation.

Original Source(s)

CRS Trial Reveals Surgery Divide

  • by Jess Allerton

  • March 18, 2026

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