Oral TYK2 Inhibition in Atopic Dermatitis
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February 5, 2026
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4 min
In a phase 2 randomized clinical trial, oral ICP-332 effectively reduced atopic dermatitis severity and pruritus in 75 adults over four weeks, demonstrating a favorable safety profile without serious adverse events. The trial showed significant mean reductions in the Eczema Area and Severity Index (EASI) score, with 64% of patients achieving a 75% improvement compared to only 8% with placebo. Conducted in China and led by Jinhua Xu, PhD, this study supports further investigation of ICP-332 as a potential treatment for moderate to severe atopic dermatitis.
1. ICP-332 reduced atopic dermatitis severity in adults.2. 75 participants aged 18-75 were involved.3. The trial showed 64% of ICP-332 patients achieved a 75% improvement.4. Treatment duration was 4 weeks.5. No serious adverse events were reported.6. Adverse events mainly mild to moderate.7. The study underscores the need for phase 3 trials.
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