Scaling Smarter: How Continuous Manufacturing Is Reshaping Drug Development
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By
February 13, 2026
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8 min
Dr. Margarethe Richter from Thermo Fisher Scientific elaborates on how twin-screw extrusion and continuous technologies streamline the scale-up process in pharmaceutical manufacturing. These systems maintain consistent conditions across different scales, enhancing precision and minimizing risks associated with scaling operations. Such capabilities are pivotal for biotechs working on rare disease treatments that require flexible production methods. Furthermore, integrating technologies like continuous granulation and 3D printing enhances efficiency while meeting regulatory standards, supporting the need for rapid innovation in the industry.
1. Twin-screw extruders solve scale-up challenges in manufacturing. 2. Continuous processes maintain stable conditions across various scales. 3. Precision and repeatability are essential for patient safety. 4. Technologies like 3D printing enhance flexibility in drug production. 5. Understanding process science is vital for biotechs to succeed. 6. Continuous granulation shortens tablet production time and reduces errors. 7. Wrong assumptions about technology can hinder implementation success.
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