MDSpire - Summary
Clinical Guidelines

POEMS Syndrome: Diagnostic Clues From Neuropathy to Bone Marrow Findings

POEMS syndrome is a poorly understood and complex paraneoplastic plasma cell disorder characterized by peripheral neuropathy and multisystem involvement, including organomegaly, endocrinopathy, monocl...

Share

POEMS syndrome is a rare plasma cell disorder characterized by peripheral neuropathy, organomegaly, and endocrinopathy, primarily caused by elevated vascular endothelial growth factor. Accurate diagnosis is often hampered by its heterogeneous presentation and resemblance to other disorders. A case study of a 62-year-old man illustrates typical symptoms such as gait difficulties and neuropathy. Recognizing clinical patterns and biomarkers such as vascular endothelial growth factor levels is crucial for timely diagnosis and treatment to prevent severe morbidity and mortality.

Original Source(s)

POEMS Syndrome: Diagnostic Clues From Neuropathy to Bone Marrow Findings

  • by Syed Ali Abutalib, Angela Dispenzieri

  • March 24, 2026

Related Content

Dynamic, Accessible Risk Stratification Tool Created for Smoldering Multiple Myeloma

Researchers have developed a dynamic risk stratification tool for patients with smoldering multiple myeloma to predict their chance of progression to active multiple myeloma. The tool, called Precurso...

ASH 2025: Myelofibrosis Roundup

For myelofibrosis, the treatment landscape is poised for change as new targets have emerged, and treatments are evolving beyond the standard Janus kinase (JAK) inhibitors. Novel therapies are being pa...

ASH 2025: Myelofibrosis Roundup

For myelofibrosis, the treatment landscape is poised for change as new targets have emerged, and treatments are evolving beyond the standard Janus kinase (JAK) inhibitors. Novel therapies are being pa...