From the Journals
Clinical Guidelines

AGA unveils new clinical practice guideline for Crohn's disease

Of the 16 recommendations, the panel rated one as “strong,” nine as “conditional,” and six as “knowledge gaps.”

Share

The AGA has introduced a new living clinical guideline for the pharmacologic management of moderate-to-severe Crohn’s disease, advocating for early advanced therapies over traditional corticosteroid-first approaches. This update follows the approval of new treatments since the last guidelines in 2021. A panel conducted a meta-analysis to evaluate 11 medications, yielding 16 recommendations. Notably, this guideline emphasizes shared decision-making between clinicians and patients, underlining the importance of personalized treatment strategies based on individual care contexts.

Original Source(s)

AGA unveils new clinical practice guideline for Crohn's disease

Of the 16 recommendations, the panel rated one as “strong,” nine as “conditional,” and six as “knowledge gaps.”

  • by Doug Brunk

  • November 25, 2025

  • 5 min