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Sudden Death Trajectories in HFpEF, HFmrEF

Clinical changes before death overlap across outcomes

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A recent study analyzed the functional and health status changes in heart failure patients with preserved or mildly reduced ejection fraction prior to sudden death. The study involved 6,001 patients, revealing a gradual decline in symptoms and rising natriuretic peptide levels before death, while patients who survived showed improvement. The findings highlight the non-specific nature of these changes, complicating risk stratification for sudden death. Current guidelines do not recommend implantable cardioverter-defibrillators for primary prevention due to these limitations.

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Sudden Death Trajectories in HFpEF, HFmrEF

  • by Kathryn Wighton

  • March 31, 2026

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