Rhinosinusitis: Sex-Based Differences
November 3, 2025
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3 min
A comprehensive analysis involving over 258,000 adults revealed sex-based differences in chronic rhinosinusitis (CRS) diagnoses, with 12% prevalence in women compared to 9% in men. Women were more likely to have chronic rhinosinusitis without nasal polyps (CRSsNP) and less likely to have it with polyps (CRSwNP). Findings indicated that women had lower eosinophil counts and immunoglobulin E levels than their male counterparts. These disparities emphasize the need to incorporate biological sex considerations in CRS research and treatment strategies.
1. 12% of women versus 9% of men diagnosed with chronic rhinosinusitis (CRS). 2. Women showed higher rates of CRSsNP compared to CRSwNP. 3. Lower eosinophil counts and IgE levels in women, indicating reduced type 2 inflammation. 4. Age impacts CRSsNP likelihood, especially in women. 5. Emphasizes biological sex in CRS treatments. 6. Study based on NIH All of Us Research Program data. 7. Limitations included potential selection bias and reliance on coded diagnoses.
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