Gene Test Guides Eczema Care
Skin scraping assay may help labs support targeted systemic treatment in atopic dermatitis
A 487-gene expression profile test revealed that patients with atopic dermatitis could be categorized into responders to Janus kinase (JAK) inhibitors or Th2-targeted biologics. Conducted as a prospective, multicenter study, researchers utilized noninvasive skin scrapings to validate this test, which aims to enhance the efficacy of systemic therapy selection for moderate-to-severe atopic dermatitis. The test facilitates precision medicine by enabling clinicians to tailor treatments based on individual molecular profiles, potentially leading to improved outcomes in disease management.
1. A 487-gene expression profile test was developed for atopic dermatitis. 2. The study identifies JAK inhibitor responders vs. Th2 biologic responders. 3. Noninvasive skin sampling was used for testing. 4. Higher clearance and symptom control were seen in JAK responders. 5. The assay aids in therapy selection tailored to molecular profiles. 6. Only patients aged 12+ were validated in the study. 7. Aim to enhance patient outcomes and streamline systemic therapy.