Case Report Shows Carbimazole's ‘Triple-Hit’ - Summary - MDSpire
From the Journals

Case Report Shows Carbimazole's ‘Triple-Hit’

Diffuse alveolar hemorrhage with coexistent antiphospholipid syndrome complicated anticoagulation therapy and created competing bleeding and thrombosis risks.

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A 29-year-old female patient with a 15-year history of hyperthyroidism treated with carbimazole presented with acute hemoptysis and type 1 respiratory failure. Imaging revealed ground-glass opacities indicating diffuse alveolar hemorrhage and laboratory tests confirmed myeloperoxidase–antineutrophil cytoplasmic antibody-associated vasculitis, alongside antiphospholipid syndrome. Following plasmapheresis and immunosuppressive therapy with methylprednisolone and cyclophosphamide, the patient achieved clinical and radiological remission, allowing for the careful reintroduction of carbimazole.

Original Source(s)

Case Report Shows Carbimazole's ‘Triple-Hit’

  • by Andrea Surnit

  • April 1, 2026

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