When Thyroid and Parathyroid Collide
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By
January 26, 2026
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3 min
A recent case report in Sage Open Pathology details the rare occurrence of an intrathyroidal parathyroid adenoma coexisting with papillary thyroid carcinoma in the same thyroid lobe, marked by the carcinoma's direct invasion of the adenoma. This case involved a 63-year-old woman with hypercalcemia and elevated parathyroid hormone levels indicative of primary hyperparathyroidism. The findings emphasize the potential for misdiagnosis of intrathyroidal lesions as benign nodules, highlighting the necessity for detailed histological evaluation and clinicopathologic correlation in such cases.
1. Case of intrathyroidal parathyroid adenoma and papillary thyroid carcinoma reported. 2. 63-year-old woman presented with hypercalcemia. 3. Preoperative imaging misidentified the lesion. 4. Papillary thyroid carcinoma directly invaded parathyroid adenoma. 5. Emphasis on thorough histologic examination for accurate diagnosis. 6. Importance of clinicopathologic correlation. 7. Rare occurrence and implications for surgery.
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