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Retinal Changes Linked to PCOS

Meta-analysis of OCT and OCT angiography studies found thicker retinal nerve fiber layers and slightly thinner central macula in patients with polycystic ovary syndrome.

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A systematic review and meta-analysis published in Cureus revealed that patients with polycystic ovary syndrome (PCOS) exhibit distinct retinal structural differences compared to healthy individuals. The analysis, encompassing 15 studies with 1,370 women, indicated thicker retinal nerve fiber layers and slightly thinner central maculas in PCOS patients. Although changes in choroidal thickness were noted, the evidence for these findings varied in certainty, with significant implications for understanding the ocular health of women with PCOS, despite unchanged retinal microvascular density.

Original Source(s)

Retinal Changes Linked to PCOS

  • by Julie Greenbaum

  • March 16, 2026

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