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UTI Prophylaxis Raises Resistance Risk

Study finds more resistance on culture, no significant rise in severe infections

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A retrospective cohort study analyzed data from the Secure Anonymised Information Linkage Databank in Wales, involving 48,297 women aged 18 and older with recurrent urinary tract infections (UTIs) between 2015 and 2020. Among these, 839 women received prophylactic antibiotics, most commonly nitrofurantoin, trimethoprim, or cefalexin. While increased antimicrobial resistance was found in urine cultures for those on prophylaxis, no significant rise in hospital admissions for antibiotic-resistant infections was noted. This highlights an important distinction between microbiological resistance and clinical outcomes, suggesting a complex approach is needed in managing UTIs.

Original Source(s)

UTI Prophylaxis Raises Resistance Risk

  • by Jess Allerton

  • March 30, 2026

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