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PFAS Bioaccumulation: The Biology of Forever

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  • February 23, 2026

  • 20 min

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Carrie McDonough, an Associate Professor of Chemistry at Carnegie Mellon University, emphasizes the need for new risk assessment models for PFAS due to their unique bioaccumulation behavior. Unlike traditional pollutants, PFAS interact with proteins and phospholipids, complicating their risk assessment and exposure evaluation. Her research also focuses on identifying unknown organofluorine compounds that contribute to PFAS toxicity. By employing advanced analytical techniques, McDonough aims to enhance our understanding of PFAS distribution in biological systems and their long-term health impacts.

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