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A Closer Look at Vascular Cell States in Marfan Syndrome

Single-cell proteomics identifies Marfan-enriched smooth muscle states and endothelial transition signatures

  • March 25, 2026

  • 2 min

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A study has uncovered distinct vascular cell states in Marfan syndrome using a label-free single-cell proteomics approach. Researchers analyzed nearly 5,000 cells from the aortic roots of wild-type and Fbn1C1041G/+ mice, identifying key cell types such as endothelial cells and various smooth muscle cell subtypes. Their findings highlighted significant differences in smooth muscle cell states associated with Marfan syndrome, particularly changes linked to aneurysm development. The integration of proteomic and transcriptomic data revealed additional Marfan-specific states, indicating a need for further functional studies.

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A Closer Look at Vascular Cell States in Marfan Syndrome

  • March 25, 2026

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