Synbiotic Supplement Reduced Multiple Inflammatory Proteins
October 24, 2025
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4 min
A recent trial demonstrated that a daily synbiotic comprising 27 bacterial cultures and a multifiber prebiotic blend significantly decreased various inflammation-related proteins compared to omega-3 and inulin supplements. Conducted by Dr. Amrita Vijay and colleagues from the University of Nottingham, the study found notable declines in IL-6, SIRT2, 4EBP1, and CCL23 among participants consuming the synbiotic. Additionally, increased serum butyrate correlated with lower IL-6 levels, suggesting potential gut-immune interactions, although limitations in sample size and study design were noted.
1. Synbiotic with 27 bacterial cultures may lower inflammation proteins. 2. Significant protein declines include IL-6, SIRT2, and CCL23. 3. Higher butyrate levels inversely correlated with IL-6. 4. Omega-3 and inulin produced narrower biomarker changes. 5. Limitations include small sample sizes and study design constraints. 6. Future research should include longer follow-ups and microbiome profiling.
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