Recent research conducted by a team from Boston Children’s Hospital and affiliated institutions has highlighted distinct chemical signatures of pathological tau protein across various neurodegenerative diseases. Utilizing a novel technique called FLEXITau, researchers analyzed post-mortem brain tissue from 203 individuals affected by six different tauopathies, including Alzheimer's disease and chronic traumatic encephalopathy. This study emphasizes that each tauopathy has a unique combination of post-translational modifications and cleavage patterns, providing crucial insights for diagnostic and therapeutic applications.
1. Study by Boston Children’s Hospital on tau protein. 2. Focuses on distinct chemical signatures in tauopathies. 3. Used FLEXITau for mass-spectrometry analysis. 4. Mapped 145 post-translational modifications. 5. Machine learning ranked modifications for disease classification. 6. Absolute quantification is crucial for diagnostics and drug design. 7. Each tauopathy has unique modification patterns.
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