From the Journals

Sex-Stratified Genome Analysis Maps Depression Variants

X-chromosome variant and higher heritability distinguish male and female depression genetics.

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A comprehensive genome-wide association study reveals sex-specific genetic differences in major depressive disorder (MDD), identifying 16 variants in females and 8 in males from a dataset of over 130,000 individuals. Significant findings include a novel male variant on the X chromosome and higher heritability in females, suggesting a stronger genetic basis for depression. The study indicates a shared genetic foundation between sexes but emphasizes the need for precision medicine tailored to sex-specific genetic profiles. Dr. Brittany L. Mitchell of Queensland Institute highlights potential therapeutic implications.

Original Source(s)

Sex-Stratified Genome Analysis Maps Depression Variants

X-chromosome variant and higher heritability distinguish male and female depression genetics.

  • by Stanley Gajete

  • October 23, 2025

  • 3 min

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