Plasma pTau217 Cutoffs for Clinical Use
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By
February 4, 2026
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4 min
A recent study indicates that kidney dysfunction and anemia lead to elevated plasma phosphorylated tau 217 (p-tau217) levels, complicating diagnostic classifications for Alzheimer’s disease when standard cutoffs are used. In a multicenter cohort, employing subgroup-specific p-tau217 cutoffs significantly enhanced diagnostic accuracy, especially in patients with advanced chronic kidney disease. This research involved 2,571 participants and proposes a double-cutoff strategy to maximize efficiency, though it generates numerous intermediate results necessitating further imaging. The findings emphasize the need for tailored diagnostic approaches in varying biological contexts to optimize Alzheimer’s diagnosis.
1. Elevated p-tau217 levels due to kidney dysfunction/anemia complicate Alzheimer’s diagnostics. 2. Study utilized multicenter cohort analysis. 3. Subgroup-specific cutoffs improved diagnostic accuracy for chronic kidney disease. 4. The double-cutoff strategy shows higher accuracy but yields many intermediate results. 5. Inversely associated with glomerular filtration rate and hemoglobin. 6. Tailored approaches are necessary for precise diagnosis. 7. Future research should expand to diverse populations.
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