From the Journals

Can Testosterone Affect Cognitive Function? 

Systematic review finds modest, population-dependent effects on mood and cognition in adult men 

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Testosterone therapy may provide modest benefits for mood and cognitive function in adult men, although results are inconsistent and vary by population, as highlighted in a systematic review analyzing 11 trials with over 600 participants aged 18 to 85. While depressive symptoms showed notable improvement especially in men with treatment-resistant depression and low testosterone levels, cognitive improvements were limited to specific domains. Testosterone therapy generally improved quality of life without significant side effects, leading researchers to suggest it be considered a complementary rather than primary treatment, with careful endocrinologic monitoring advised.

Original Source(s)

Can Testosterone Affect Cognitive Function? 

Systematic review finds modest, population-dependent effects on mood and cognition in adult men 

  • by Henry Thomas

  • February 27, 2026

  • 3 min

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