Surgical Sequencing in Esophageal Cancer
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By
February 5, 2026
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3 min
A phase 3 clinical trial from Sichuan Cancer Hospital investigated treatment outcomes for locally advanced esophageal squamous cell carcinoma. Patients underwent either neoadjuvant chemoradiotherapy before surgery or surgery followed by adjuvant therapy. With a median follow-up of five years, both approaches showed similar overall and disease-free survival rates. Notably, patients achieving a pathologic complete response after neoadjuvant treatment had significantly better long-term outcomes, indicating a need for tailored treatment strategies based on individual responses.
1. The study compared neoadjuvant chemoradiotherapy and surgery with adjuvant therapy. 2. No significant overall survival difference was found. 3. Complete pathologic response greatly improved outcomes. 4. Similar adverse effect rates were observed between groups. 5. Tumor resection with negative margins was achieved in over 95% of patients. 6. Study limitations include single-center design and modest sample size. 7. Tailored treatment strategies are essential for optimal patient outcomes.
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