A New Route for RGC Survival?
Vascularizing retinal organoids offers new possibilities for preserving retinal ganglion cells inside organoids
Recent advancements in ophthalmological research reveal a method for creating transiently vascularized human retinal organoids (vROs) that significantly enhance retinal ganglion cell (RGC) survival and maturation. By incorporating endothelial cells derived from human induced pluripotent stem cells, researchers have addressed a critical limitation of traditional organoids, which often suffer from hypoxia due to lack of vascularization. This innovative approach could greatly improve modeling of retinal diseases such as glaucoma and diabetic retinopathy, providing valuable platforms for future therapeutic development.
1. Transient vascularization in retinal organoids improves RGC survival. 2. Endothelial cells are derived from human induced pluripotent stem cells. 3. RGC degeneration relates to glaucoma and optic neuropathies. 4. Enhanced vascularization addresses hypoxia issues. 5. Technology includes RT-qPCR and multielectrode arrays for testing.