RNACOREX is a newly developed computational tool designed to pinpoint disease-associated RNA regulatory networks, utilizing gene expression data to classify patient samples. By analyzing microRNA (miRNA) and messenger RNA (mRNA) interactions, it overcomes the challenges of false positives found in large databases. Incorporating both structural and functional scores for interactions, RNACOREX uses probabilistic models to provide interpretable classification results. Evaluated against data from 13 cancer types, it offers insights into RNA interactions that can guide biomarker prioritization, although clinical utility remains to be established.
1. RNACOREX is a tool for identifying RNA regulatory networks.2. It focuses on miRNA and mRNA interactions linked to disease.3. The tool filters interactions using established databases.4. It employs Conditional Linear Gaussian classifiers for analysis.5. Evaluated on data from 13 cancer types in The Cancer Genome Atlas.6. Provides interpretable results and network visualizations.7. Aids in prioritizing biomarkers and regulatory pathways.8. Clinical utility is not established by RNACOREX itself.
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