What I Learned Bringing Slalom Chromatography Back from the Dead
Fabrice Gritti spent a year immersed in the world of DNA physics to resurrect a long-abandoned technique to solve modern challenges in cell and gene therapy analysis
A new approach to slalom chromatography (SC) has emerged to address the challenges in separating large DNA and RNA macromolecules critical for cell and gene therapy. Initiated by the late Edward Bouvier's foresight over a decade ago, researchers at Waters re-evaluated SC, delving into both theoretical and experimental frameworks. Through systematic investigations, they uncovered mechanisms governing the migration of DNA and RNA biopolymers. The result is the development of the first commercially viable SC column, promising advancements in biopharmaceuticals.
