When Thyroid and Parathyroid Collide
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By
January 12, 2026
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3 min
A recent case presented in Sage Open Pathology details a rare occurrence in endocrine pathology involving a 63-year-old woman with primary hyperparathyroidism. It describes the first documented infiltration of an intrathyroidal parathyroid adenoma by papillary thyroid carcinoma within the same lobe, complicating diagnosis and preoperative localization. Despite imaging studies suggesting a benign lesion, surgical histopathology revealed both conditions, emphasizing the necessity for comprehensive microscopic evaluation in similar cases to avoid diagnostic pitfalls in endocrine pathologies.
1. Case involved a 63-year-old woman with hyperparathyroidism. 2. Documented coexistence of parathyroid adenoma and papillary thyroid carcinoma. 3. Diagnostic challenges arose from imaging misidentifying the adenoma. 4. Histopathologic examination revealed carcinoma invading the adenoma. 5. Need for thorough evaluation in thyroidectomy specimens. 6. Importance of differential diagnosis in hyperparathyroidism cases. 7. Parathyroid hormone washout enhances accuracy in fine-needle aspiration biopsies.
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