AI Models Predict CNS Tumors From Spinal Fluid
November 15, 2025
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2 min
Artificial intelligence (AI) models developed by researchers from Soonchunhyang University can enable earlier, noninvasive identification of pathogenic variants in central nervous system (CNS) tumors. By integrating genetic data from cerebrospinal fluid (CSF) and imaging data from MRI, these models assist clinicians in predicting tumor biology and guiding treatment prior to surgery. The study presented at the AMP 2025 in Boston found that combining the outputs of two machine-learning models significantly enhances diagnostic accuracy and may improve clinical workflows in neuro-oncology.
1. AI models can identify pathogenic variants in CNS tumors noninvasively. 2. The study used genetic and imaging data integration for improved accuracy. 3. Two models were developed: a dense neural network and a convolutional neural network. 4. Highest accuracy achieved by the dense neural network was an MCC of 0.8822. 5. Early intervention and personalized treatment are potential benefits of this technology. 6. Misclassifications mainly occurred between glial and nonglial tumors.
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