Botulinum Toxin Evaluated in Digital Ischemia - Summary - MDSpire
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Botulinum Toxin Evaluated in Digital Ischemia

Individual-level meta-analysis examines response, dosing, and safety across ischemic etiologies

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A systematic review and individual participant data meta-analysis demonstrated that botulinum toxin injections significantly improve outcomes in patients suffering from digital ischemia, ulcers, and gangrene, particularly in autoimmune conditions like systemic sclerosis. The analysis of 31 studies with 119 participants showed a high complete response rate, with 93% for acute digital ischemia and 90% for ulcers. Most patients achieved benefits with minimal adverse events, making botulinum toxin a promising treatment option, especially when traditional therapies fail.

Original Source(s)

Botulinum Toxin Evaluated in Digital Ischemia

  • by Kathryn Wighton

  • April 3, 2026

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