Long-Term Proton Pump Inhibitors and Oral Anticoagulants May Be Linked to Anemia
Long-term use of proton pump inhibitors and oral anticoagulants may be linked to an increased risk of developing iron deficiency anemia in adult patients.
Long-term use of proton pump inhibitors and oral anticoagulants has been associated with an increased risk of developing iron deficiency anemia in adults, as revealed in a recent case-control study. The study findings show that long-term exposure to proton pump inhibitors and oral anticoagulants was linked to a higher risk of iron deficiency anemia, with proton pump inhibitors showing a higher odds ratio. Furthermore, the association between oral anticoagulants and iron deficiency anemia was predominantly observed in patients with underlying hemorrhagic lesions in the gastrointestinal tract, indicating a possible chronic blood loss mechanism. The authors disclosed no specific funding for this research.
1. Long-term use of proton pump inhibitors and oral anticoagulants associated with increased risk of iron deficiency anemia in adults. 2. Proton pump inhibitors showed a higher odds ratio for iron deficiency anemia. 3. Oral anticoagulants linked to iron deficiency anemia predominantly in patients with hemorrhagic lesions. 4. No significant associations found for long-term use of antidepressants, antiplatelet agents, or nonsteroidal anti-inflammatory drugs. 5. Authors disclosed no specific funding for this research.