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Long-Term Proton Pump Inhibitors and Oral Anticoagulants May Be Linked to Anemia

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Long-term use of proton pump inhibitors and oral anticoagulants has been associated with an increased risk of developing iron deficiency anemia in adults, as revealed in a recent case-control study. The study findings show that long-term exposure to proton pump inhibitors and oral anticoagulants was linked to a higher risk of iron deficiency anemia, with proton pump inhibitors showing a higher odds ratio. Furthermore, the association between oral anticoagulants and iron deficiency anemia was predominantly observed in patients with underlying hemorrhagic lesions in the gastrointestinal tract, indicating a possible chronic blood loss mechanism. The authors disclosed no specific funding for this research.

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