From the Journals

Smarter Digital Morphology Triage

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  • January 30, 2026

  • 3 min

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A recent study in Nature Machine Intelligence presents CytoDiffusion, a generative AI model for classifying blood cell images and identifying morphologies needing specialist review. Challenges in automating leukocyte morphology classification stem from variations in cell appearance due to staining, preparation, and disease states. Unlike traditional discriminative models, CytoDiffusion utilizes a diffusion-based generative approach to enhance performance under diverse conditions. Trained on over 32,000 images, it demonstrated competitive performance compared to existing classifiers while improving uncertainty handling and anomaly detection.

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