Plasmonic COF Nanofilms Expand the Reach of Mass Spectrometry Imaging - Summary - MDSpire
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Plasmonic COF Nanofilms Expand the Reach of Mass Spectrometry Imaging

A gold-decorated covalent organic framework grown on titanium dioxide nanotubes enables matrix-free imaging across plants, fingerprints, fruits, and brain tissue

  • April 7, 2026

  • 2 min

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Researchers have developed a novel nanostructured surface that enhances mass spectrometry imaging, overcoming longstanding sample preparation challenges. By integrating gold nanoparticle-decorated covalent organic framework nanofilms with titanium dioxide nanotubes, this new platform provides a matrix-free surface for effective imaging. It demonstrates improved ion signals and cleaner low-mass spectra, enabling the analysis of diverse samples from whole plants to cryo-sectioned brain tissues. The method is shown to efficiently map pollutants and metabolites, offering insights into biological samples.

Original Source(s)

Plasmonic COF Nanofilms Expand the Reach of Mass Spectrometry Imaging

  • April 7, 2026

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