From the Journals

APOE Utilization Tied to Most AD Cases

Apolipoprotein E ε3 and ε4 genotypes account for most Alzheimer's disease and nearly half of all-cause dementia.*

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A population-based study analyzing over 470,000 participants revealed that 93% of neuropathologically confirmed Alzheimer's disease cases are linked to apolipoprotein E ε3 and ε4 alleles. This research, published in npj Dementia, aggregates data from multiple sources including UK Biobank and FinnGen. It demonstrates a clear gradient in Alzheimer's risk associated with different APOE genotypes, prompting recommendations for prioritizing interventions on APOE to improve dementia prevention strategies. Limitations include focus on European ancestry and varying outcome ascertainment methods.

Original Source(s)

APOE Utilization Tied to Most AD Cases

Apolipoprotein E ε3 and ε4 genotypes account for most Alzheimer's disease and nearly half of all-cause dementia.*

  • by Kathryn Wighton

  • January 20, 2026

  • 3 min

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