Organ Damage, BMI Linked to Fatigue in SLE - Summary - MDSpire
From the Journals

Organ Damage, BMI Linked to Fatigue in SLE

Cross-sectional study suggests fatigue is associated with damage accrual and body mass, not disease activity

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A study published in BMJ Open by researchers from the National Institute of Arthritis and Musculoskeletal and Skin Diseases examined clinically significant fatigue in 183 patients with systemic lupus erythematosus (SLE). The results revealed that fatigue was linked to increased organ damage and higher body mass index, not correlated with disease activity. Notably, 52% of participants reported significant fatigue, with racial disparities noted. The findings suggest that fatigue in SLE may be influenced more by cumulative organ damage rather than current disease activity and emphasize the need for further longitudinal studies.

Original Source(s)

Organ Damage, BMI Linked to Fatigue in SLE

  • by Andrea Surnit

  • April 20, 2026

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