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Mapping the Metabolism of Plant Mixtures 

A multilayer networking workflow reveals mixture-dependent metabolism of kratom alkaloids A multilayer networking workflow reveals mixture-dependent metabolism of kratom alkaloids 

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  • March 10, 2026

  • 3 min

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Researchers have developed a new analytical workflow using high-resolution mass spectrometry coupled with multilayer molecular networking to study the metabolism of complex plant-derived chemical mixtures, exemplified by kratom (Mitragyna speciosa). This innovative method allows for the simultaneous analysis of multiple compounds, revealing how individual alkaloids, including opioid receptor agonist mitragynine, are metabolized within botanical mixtures. By simulating hepatic biotransformation with human liver extracts, the team identified both phase I and phase II metabolites, paving the way for a transformative approach in natural products research.

Original Source(s)

Mapping the Metabolism of Plant Mixtures 

A multilayer networking workflow reveals mixture-dependent metabolism of kratom alkaloids A multilayer networking workflow reveals mixture-dependent metabolism of kratom alkaloids 

  • March 10, 2026

  • 3 min

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