From the Journals

Mediterranean Metabolite Signature Tied to Lower RA, Study

66-metabolite signature explains 22.4% of the Mediterranean diet–RA relationship.

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A prospective cohort study involving 109,565 UK Biobank participants revealed a significant association between adherence to the Mediterranean diet and a reduced risk of rheumatoid arthritis (RA), with those in the highest quintile showing a 32% lower incidence. The study emphasized a dose-response relationship and identified a metabolic signature of 66 metabolites linked to the diet. Researchers posited that the metabolic signature captures the biological response to dietary patterns, influencing RA risk independent of genetic predispositions.

Original Source(s)

Mediterranean Metabolite Signature Tied to Lower RA, Study

66-metabolite signature explains 22.4% of the Mediterranean diet–RA relationship.

  • by Stanley Gajete

  • October 21, 2025

  • 4 min

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